Familial Mediterranean fever: exploring the causal relationship between chronic inflammation and amyloidosis

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Aviva Yaffa Rostas
Tamara Hoppe
Nicole Sitzer


Familial Mediterranean Fever, Amyloidosis, Colchicine, Periodic Fever Syndrome


Familial Mediterranean Fever is a hereditary periodic fever syndrome primarily affecting Mediterranean populations and manifesting with recurrent attacks of fever and serositis. As with many chronic inflammatory states, amyloidosis is a serious complication. Colchicine is used to manage FMF by reducing inflammation and preventing secondary amyloidosis, but has several undesired effects. We present a patient with FMF complicated by amyloidosis and renal failure. Through this case presentation, we will discuss chronic inflammation as an underlying cause of systemic amyloidosis.