Increased risk of cardiovascular disease by diabetes-induced molecular disturbances

Main Article Content

Dorrin Zarrin Khat
Mansoor Husain

Keywords

Diabetes Mellitus, Cardiovascular Disease, Diabetic Cardiomyopathy, Mechanism, Insulin Resistance, Metabolism, Oxidative Stress, Calcium Handling, Neurohormonal Activation, Treatment.

Abstract

The incidence and prevalence of Type-2 diabetes mellitus (T2DM) is increasing worldwide, with diabetic cardiomyopathy representing one of its cardiovascular complications. Indeed, cardiovascular disease (CVD) is the major cause of morbidity and mortality among patients with T2DM. The relationship linking diabetes and CVD is complex and multifactorial, and a thorough understanding of the pathophysiological mechanisms underlying diabetes-induced cardiac damage is crucial to the development and improvement of treatment strategies for patients with T2DM at high risk of major adverse cardiovascular events (MACE). This review summarizes the molecular mechanisms of certain key contributors to the progression of diabetic cardiomyopathy including, insulin resistance, metabolic disturbances, oxidative stress, altered Ca2+ handling, and neurohormonal activation.