Lactobacillus reuteri's role in the prevention of colorectal cancer: a review of literature

Main Article Content

Karlyle Bistas
Evangelos Bistas
Edwin Mogaka

Keywords

Abstract

Background: Probiotics have many health benefits, which include decreasing intestinal inflammation and down-regulating metabolites and inflammatory mediators that can lead to the progression of tumors. Lactobacillus reuteri (L. reuteri) is a crucial bacterium that colonizes many mammals. Through analysis and evaluation of peer-reviewed articles relevant to the topic of interest, the findings in this review suggest that L. reuteri can slow tumor progression.


Hypothesis: Lactobacillus reuteri facilitates the prevention of colorectal cancer through inhibition of tumor progression.


Methodology: A database search through MEDLINE with exclusion criteria narrowed down material to the most relevant searches. The similarities that existed between various articles are highlighted in summary findings to help strengthen the argument for L. reuteri.


Conclusion: The findings of this review support the hypothesis that states, "Lactobacillus reuteri facilitates probiotics in the prevention of colorectal cancer through inhibition of tumor progression." L. reuteri was able to prevent colorectal cancer in animal models through the inhibition of tumor progression. Findings showed that this bacterium was critical in the inhibition of tumor progression, the reduction in inflammation, and thus the prevention of tumor progression into carcinogenesis or further metastasis.