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Background: The aims of this study were to determine the effect of weight loss on biochemical parameters and anthropometric measurements in prolactinoma patients and to evaluate the effectiveness of weight loss diet along with medical treatment.
Methods: Twenty-two patients with prolactinoma were divided into two groups and one of the groups was applied weight loss diet (diet group) while the other group was diet free (control group). Each participant was interviewed using a structured questionnaire. The biochemical parameters (fasting plasma glucose, fasting plasma insulin, prolactin, leptin, TSH, T4, cortisol, HbA1c, AST, ALT and blood lipids) of participants were analyzed and anthropometric measurements were taken.
Results: There was a significant change in mean BMI after treatment in diet group (p=0.000). The mean level of serum prolactin decreased from 45.1±31.63 ng/dL at baseline to 12.6±8.19 ng/dL after three months in diet group (p=0.006). Despite there being no statistically significant difference between diet and control group in terms of baseline level of prolactin measurement (p=0.800), statistically significant difference between the two groups in terms of final level of prolactin measurement (p=0.027) was observed. There was a significant change in mean level of leptin after treatment in diet group (p=0.001).
Conclusions: In addition to medical treatment, weight loss diets sped up the healing process for hyperprolactinemia and the reduction in body weight had positive effects on the metabolic profiles of prolactinoma patients.