Association of Erythrocytes Indices and Interleukin-1 beta with Metabolic Syndrome Components Erythrocyte indices, IL-1β and metabolic syndrome

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Adel Abdel Moneim
Basant Mahmoud
Eman Sultan
Rania Mahmoud

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Abstract

Background and Aim: The hematological studies and cytokines are of great importance in metabolic syndrome pathophysiology. The study aimed to illuminate the association between red blood cell (RBCs) indices and interleukin-1beta (IL-1β) with MetS components among adults' Egyptian patients.


Material and Methods: A total of 100 healthy subjects and 200 patients diagnosed with MetS components were enrolled. Eligible patients were classified into four groups (50 patients). Group1 included patients with 2 MetS criteria, group2 those had 3 MetS criteria, group3 those with 4 MetS criteria and group 4 those had 5 MetS criteria.


Results: Among MetS patients, the data revealed that RBCs count and hematocrit % showed an obvious higher in both group 2 and 3, however, hemoglobin (HB) and mean corpuscular volume levels showed a significant elevation in group 3 compared to healthy controls. Group 4 observed a noticeable lower in both RBCs count and HB concentration compared healthy controls. Moreover, red blood cell distribution width value was significantly higher in all groups compared to healthy controls. Additionally, IL-1β was significantly higher in all patients with MetS components compared to the healthy group. Concerning group 3, a positive correlation between both RBCs count and hematocrit level with systolic blood pressure was recorded, while HB concentration was correlated with diastolic blood pressure. Conclusions: Erythrocyte indices and IL-1β levels are associated with an increase in MetS components, and this study provides additional evidence for the use of hematological and cytokine markers in early identification of individuals at risk of MetS.